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Eli Lilly Stock Moves Lower Despite Analyst’s Bullish Stance

Asktraders News Team trader
Updated 17 Oct 2025

Eli Lilly's stock (NYSE:LLY) experienced a decline in after-hours trading following a White House and FDA joint media conference. The market reacted to the omission of the company's experimental oral GLP-1 receptor agonist, orforglipron, from a list of drugs selected to receive the new Commissioner's National Priority Vouchers, and coupled with comments from the administration around GLP-1 pricing.

Despite this, Cantor Fitzgerald maintains an “Overweight” rating on the stock, with a price target of $925.

Following the announcement, Eli Lilly's stock faced immediate selling pressure, and currently trades 4.47% lower in the pre-market. The absence of orforglipron from the priority voucher list, alongside broader uncertainty regarding the future pricing of GLP-1 drugs, contributed to this initial negative sentiment. This development introduces a degree of uncertainty into the near-term outlook for the company's weight-loss drug pipeline.

Cantor Fitzgerald acknowledges the potential headwinds but remains optimistic about Eli Lilly's long-term trajectory. The firm suggests that while the policy announcements may trigger short-term volatility, they do not fundamentally alter the company's underlying growth prospects.

This perspective provides a counterpoint to the immediate market reaction, suggesting a belief in Eli Lilly's resilience and future performance.

Operationally, Eli Lilly has been strategically expanding its manufacturing capabilities within the United States. A significant $5 billion investment in a Virginia facility is part of a larger $27 billion U.S. expansion plan, aiming to bolster domestic production and mitigate potential supply chain disruptions. This proactive approach to infrastructure development underscores the company's commitment to long-term growth and operational stability.

However, Eli Lilly faces competitive pressures in the rapidly evolving weight-loss drug market. Earlier results from late-stage trials of orforglipron, showing a 12.4% weight loss over 72 weeks, fell short of market expectations and the performance of Novo Nordisk’s Wegovy. This contributed to a previous 13% drop in Eli Lilly's shares, highlighting the sensitivity of the stock to clinical trial outcomes and competitive dynamics.

Price Targets

The overnight dip continuing through the morning highlights the market's immediate reaction to policy uncertainties and competitive dynamics, though Cantor Fitzgerald's steadfast support suggests that the long-term investment thesis in LLY remains intact. Not an easy one to pick through.

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