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Vertex Pharmaceuticals Stock (NASDAQ: VRTX)

Nasdaq Healthcare Biotechnology

$540.00 +$10.31 (+1.95%)
At close: 29 Oct 2026

VRTX Stock Chart

Key Statistics

Market Cap
$134.17bn
P/E Ratio (TTM)
30.85
EPS (TTM)
$17.17
Dividend Yield
0.00%
52-Week Range
$403.16 – $560.25
Day Range
$534.02 – $546.60
Volume
1,536,463
Avg. Volume (50 Days)
1,110,953
Beta
0.28
50-Day Average
$522.84
200-Day Average
$478.67
Shares Outstanding
253.30m

About Vertex Pharmaceuticals

Vertex Pharmaceuticals is a biotechnology company that develops medicines for serious diseases in specialty markets, with cystic fibrosis its main area. Its cystic fibrosis range includes Trikafta (sold as Kaftrio in Europe), Alyftrek, Symdeko, Orkambi and Kalydeco. It also sells Casgevy for sickle cell disease and transfusion dependent beta thalassemia, and Journavx for acute pain in adults. Most sales go through specialty pharmacies and distributors.

Beyond its marketed products, Vertex runs a pipeline of experimental treatments. These include an mRNA therapy for cystic fibrosis, inaxaplin for APOL1-mediated kidney disease, and candidates for type 1 diabetes, myotonic dystrophy type 1 and polycystic kidney disease. A clinical-stage arm works on rare endocrine diseases and related tumours. It also collaborates with AbCellera Biologics on T-cell engagers for autoimmune conditions. Founded in 1989.

Sector
Healthcare
Industry
Biotechnology
Listed
NASDAQ: VRTX
Listed Since
24 Jul 1991
Headquarters
Boston, MA
Country
USA
Employees
6,400
Year End
December
Website
vrtx.com

Earnings

Next Earnings
2 Nov 2026
Last Results
3 Aug 2026
Beat estimates
EPS Est. (Next)
$4.36
EPS Est. (FY 2026)
$15.24
20 analysts
Last EPS
$4.20
EPS – Reported vs Estimated
Jun 25
Sep 25
Dec 25
Mar 26
Jun 26

Estimated EPS Reported EPS

Quarter Ended Estimate Reported EPS Surprise Reported
Jun 2026 $4.15 $4.20 +1.20% 3 Aug 2026
Mar 2026 $4.31 $4.47 +3.81% 4 May 2026
Dec 2025 $5.15 $5.03 −2.33% 12 Feb 2026
Sep 2025 $4.58 $4.80 +4.80% 3 Nov 2025
Jun 2025 $4.25 $4.52 +6.35% 4 Aug 2025
Mar 2025 $4.29 $4.06 −5.36% 5 May 2025
Dec 2024 $4.02 $3.98 −1.00% 10 Feb 2025
Sep 2024 $4.13 $4.38 +6.05% 4 Nov 2024

Ownership

Institutions
98.17%
Insiders
0.21%
Short Interest
1.90%
Free Float
252.68m
Institutional Holder Shares % Owned Change
Capital World Investors 26.12m 10.30% +2.94%
BlackRock Inc 24.11m 9.51% +0.58%
Capital Research Global Investors 19.49m 7.69% −7.74%
Vanguard Capital Management, LLC 16.58m 6.54% +0.41%
State Street Corp 11.87m 4.68% +1.20%
Amvescap Plc. 8.04m 3.17% +1.91%
JPMorgan Chase & Co 6.52m 2.57% −7.33%
Geode Capital Management, LLC 6.02m 2.37% −1.98%
Vanguard Portfolio Management, LLC 4.88m 1.92% −5.18%
Capital Research & Mgmt Co - Division 3 4.70m 1.85% −8.41%

Our Analysis

Vertex Pharmaceuticals stock (NASDAQ: VRTX) has been trading in a range for the past 18 months. The global biotechnology company headquartered in Boston, Massachusetts is particularly renowned for its groundbreaking work in developing treatments for cystic fibrosis (CF).

Over the past decade, Vertex has transformed the landscape of CF care, shifting from a condition with limited treatment options to one where disease-modifying therapies are available for a significant portion of the patient population.

Recent developments, including the FDA approval of a novel pain medication, strategic shifts in research, and financial performance fluctuations, have added layers of complexity to the company’s narrative, influencing investor sentiment and future prospects.

Vertex has experienced mixed results recently. In the first quarter of 2025, the company reported revenues of $2.77 billion, a 2.7% increase year-over-year. The stock trades on the Nasdaq, under ticker VRTX.

Vertex Pharmaceuticals Share Price Targets

Analysts have set a 12-month price target for Vertex with an average expectation of $500.02, ranging from a high of $621.00 to a low of $330.00.

The current consensus average target suggests a potential increase of 13.12% from the most recent trading price.

Our View: You would be wise to consider the views of the analyst community in conjunction with the fundamentals surrounding the company to properly determine a value for the stock that you feel is appropriate.

At the upper end of analysts estimates it would be easy to get carried away with the potential gains on show, but the flipside is that these targets can shift within the blink of an eye and that the view of analysts is very dynamic.

If you are considering swing trading, or day trading Vertex Pharmaceuticals shares that is a separate consideration, but for those planning for the long haul, fundamental analysis is king.

Vertex Pharmaceuticals – The Basics Driving The Business

Vertex’s core business revolves around the discovery, development, and commercialization of therapies for serious diseases. For many years, the company’s primary focus was cystic fibrosis, a genetic disorder that affects the lungs, digestive system, and other organs.

Through relentless research and innovation, Vertex has successfully launched a series of CFTR (cystic fibrosis transmembrane conductance regulator) modulators, including Kalydeco, Orkambi, Symdeko, and most notably, Trikafta (also known as Kaftrio outside the US). Trikafta, a triple combination therapy, has proven to be a game-changer, significantly improving lung function, reducing pulmonary exacerbations, and extending the lives of individuals with CF who have at least one F508del mutation, which accounts for a large percentage of CF patients.

The success of Trikafta has propelled Vertex to become a multi-billion-dollar company, generating substantial revenue and solidifying its position as a leader in the CF market. However, the company is keenly aware of the need to diversify its pipeline and expand its therapeutic focus beyond CF, given the finite number of patients eligible for CFTR modulators and the potential for future competition.

This strategic imperative has driven Vertex to invest heavily in research and development across several therapeutic areas, including pain management, genetic diseases, and cell therapies.

Analyst Team
Analyst Team
Team Member

The AskTraders Analyst Team features experts in technical and fundamental analysis, as well as traders specializing in stocks, forex, and cryptocurrency.

Analyst Rating

  • Strong Sell
  • Sell
  • Hold
  • Buy
  • Strong Buy
Consensus Rating
Buy (4.38/5)
Average Price Target
$571.46
Upside from Last Close
+5.8%
Number of Analysts
32

Financials

Revenue (TTM)
$12.59bn
Net Margin
35.00%
Operating Margin
38.06%
Return on Equity
23.54%
Return on Assets
11.93%
Forward P/E
24.63
PEG Ratio
2.03
Price to Sales
10.67
Price to Book
6.52
Book Value per Share
$79.92
Debt to Equity
0.21
Current Ratio
2.90
Revenue (Annual)
Dec 22
Dec 23
Dec 24
Dec 25
USD (billions) Dec 2025 Dec 2024 Dec 2023 Dec 2022
Revenue 12.07 11.02 9.87 8.93
Net Income 3.95 −0.54 3.62 3.32
Net Margin 32.7% −4.9% 36.7% 37.2%
Operating Cash Flow 3.63 −0.49 3.54 4.13
Debt to Equity 0.21 0.11 0.05 0.06

Latest News & Analysis

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Figures as of 29 Oct 2026.

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