Shares of 4D Pharma (LON: DDDD) are trading lower on Friday after announcing the voluntary discontinuation of enrollment in the Phase 2 study of MRx-4DP0004 to treat hospitalised patients with COVID-19 in the UK.
The decision was made for 4D to focus on its core LBP pipeline candidates and due to the increase in vaccination rates, declining hospitalisation rates, and progress in the MRx-4DP0004 asthma clinical trial.
4D Pharma also announced the completion of its target enrollment of 30 patients for Part A of its Phase 1/2 clinical trial of MRx-4DP0004 in patients with partly controlled asthma.
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Following the completion of enrollment of Part A, 4D pharma expects to announce topline results from these patients in the second half of this year.
The developer of live biotherapeutic products said MRx-4DP0004 is an oral, immunomodulatory, single strain LBP that has been shown to reduce airway inflammation in a pre-clinical model of severe asthma.
The first-in-human Phase 1/2 trial is a two-part trial of MRx-4DP0004 in patients taking long-term medication for asthma. The primary endpoint of Part A of the trial is safety and tolerability.
“The completion of enrollment in Part A of 4D pharma’s asthma study is an important milestone for this program. This is expected to provide further validation of the favorable safety profile of LBPs as a novel class of drug across a wide range of indications, including respiratory disease,” said Alex Stevenson, Chief Scientific Officer, 4D pharma.
4D Pharma’s share price is currently trading at 93.8p, down 2.84%.
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