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Hillstream Biopharma (HILS) Stock Surged 22.4%. Here’s Why.

Simon Mugo trader
Updated 1 Dec 2022

The Hillstream Biopharma Inc (NASDAQ: HILS) stock price surged 22.4% after revealing that it had developed proprietary targeted biologics, Knob Quatrabodies™ (HSB-1940), against PD-1.

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On a separate note, the company announced that it had signed collaboration agreements with Minotaur Therapeutics, Inc and a subsidiary of OmniAb, Inc. to advance Picobodies against the novel, unreachable and undruggable epitopes in high-value validated targets starting with PD-1.

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Hillstream Bio said that it would use the technologies licensed from Minotaur and OmniAb to develop and advance biotherapeutics against high-value validated targets. 

Picobodies are antibody “knob” domains comprised of the cysteine-rich ultralong complementary determining region (CDR) H3 sequences of 30-40 amino acids. These can potentially access challenging epitopes better than full-size antibodies can.

By combining Quatramers with their long half-life coated with a PD-1 Picobody™ to create HSB-1940, Hillstream believes it could more efficiently target novel epitopes with greater binding affinity than approved biologics. In addition, targeting PD-1 is a step toward enabling Hillstream to enter the rapidly growing Immuno-oncology (IO) therapeutics market with additional IO targets after PD-L1.

Dr Vaughn Smider, Minotaur’s Founder and CEO, stated: “We are excited to contribute our expertise to help in combining OmniAb’s OmniTaur-derived ultralong CDR H3 antibody fragments and Hillstream’s tumor-targeting Quatramers to discover and develop novel next-generation targeted cancer therapeutics.”

Randy Milby, Hillstream Biopharma’s CEO, stated: “The Picobodies which OmniAb brings to this collaboration combined with our Quatramers to create a novel and disruptive Knob Quatramer platform will be a great addition to our portfolio starting with HSB-1940. We are doubly excited that Dr Vaughn Smider, a pioneer in discovering, engineering and understanding these unique proteins, will lead Minotaur’s services. The Quatramer is a key Hillstream platform which is now poised to create novel therapeutics using “smart carriers” with multiple approaches for enhancing targeted cancer immunotherapy.”

*This is not investment advice. 

Hillstream Biopharma (HILS) stock price. 

The Hillstream Biopharma stock price surged 22.36% to trade at $0.4800, rising from Wednesday’s closing price of $0.3923. 


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Simon has over six years of professional trading experience across FX, commodities and equities. He has a strong passion for financial markets and is particularly focused on price action trading